METODOLOGIA CLINICA APPLICATA AGLI STUDI DI RICERCA

Learning Objectives

• Pharmacology: safety in therapy management

  Students will acquire knowledge about basic principles in Pharmacology, such as pharmacokinetics and pharmacodynamics, drugs mechanisms, signal transduction pathways, adverse drug reactions. Furthermore, an overview of major drug classes mainly used in hospital will be presented, to promote the correct use of drugs and to avoid eventual life-threatening adverse reactions or drug interactions.

• PATOLOGIA GENERALE APPLICATA AI TRIALS

  The aim is to give the student the basic knowledge necessary to define causes and pathogenic mechanisms involved in diseases.

Detailed Course Content

• Pharmacology: safety in therapy management

  General Pharmacology

  • Pharmacokinetics and pharmacodynamics;
  • Dose-response relationships;
  • The Drug Development Process;
  • Factors affecting response to drugs;
  • Risks and precautions for a proper drug therapy;
  • Adverse drug reactions;
  • Drug therapy during pregnancy and across the life span.

  Drug classes

  • Drugs affecting autonomic nervous system;
  • Drug therapy for depressions and anxiety disorders;
  • Drugs affecting the cardiovascular system;
  • Drugs affecting the digestive system;
  • Anti-inflammatory and anti-allergy drugs;
  • Drugs used for diabetes mellitus;
  • Basic principles in antimicrobial and antitumor chemotherapy.

• PATOLOGIA GENERALE APPLICATA AI TRIALS

  Cellular pathology: acute and chronic cell injury. Apoptosis and necrosis.

  Acute and chronic inflammation: cells and chemical mediators of inflammation. Wound healing. Fever.

  Immunology and immunopathology: innate and adaptative immunity. Immunological tolerance. Antigens and antibodies. The histocompatibility antigens and rejection of grafts. Hypersensitivity reactions. Immunodeficiencies. Autoimmune diseases.

  Oncology: chemical, physical and biological causes of tumors. Oncogenes and tumor suppressor genes. Local growth and metastasis.

Textbook Information

• Pharmacology: safety in therapy management
  1. Hitner, Nagle, Principi di Farmacologia, Zanichelli
  2. Rang, Dale, Farmacologia, Ed. Elsevier Masson
  3. Rossi, Cuomo, Riccardi, Farmacologia - Principi di base e applicazioni terapeutiche, Minerva Medica
• PATOLOGIA GENERALE APPLICATA AI TRIALS

  Pontieri et al. Patologia Generale. Piccin Nuova libraria.

  Robbins et al. Basi Patologiche Malattie: Patologia Generale. Elsevier

  Mak, Saunders. Fondamenti di Immunologia, Zanichelli.